Stage C These tumors have penetrated the prostate capsule and spread to nearby structures such as the seminal vesicles or fat next to the prostate gland. This stage is further divided into: • C-1, indicating spread just beyond the prostate; • C-2, indicating spread still in the local area but involving more of the immediately surrounding tissues. Stage C-2 will often obstruct the flow of urine, producing voiding difficulties. About half of Stage C-1 patients and 80 percent of Stage C-2 patients have unsuspected lymph node metastases when the tumor is detected. Standard Treatment The approach to Stage C cancer depends on the extent of the tumor and the patient's medical condition.